Regardless of what variation of the sickle cell disease the parent has, there inheritance probability is as follows--If an unaffected parent mates with a parent that is a carrier, there is a 25% chance that their child will have the sickle cell trait, but a 0% chance that one will have the genetic disorder. If two parents that are carriers mate, there is a 25% chance that their child will have the genetic disease, and a 50% chance that their child will have the sickle cell trait. If an affected parent is mated with a carrier, there is a 50% chance that their child will inherit the disease and a 50% chance that they will have the sickle cell trait. If two affected parents mate, there is a 100% chance that their child will inherit the genetic disorder.
Alleles of person having: Sickle cell anemia (SS), Sickle Hemoglobin C Disease (SC), sickle beta 0 thalassemia (ST0), sickle beta plus thalassemia (ST+), hemoglobin c disease (C). If a normal allele is present (A) in any of the genotypes, example “AS”, the person is a carrier. (Vedro, 2002).
Alleles of person having: Sickle cell anemia (SS), Sickle Hemoglobin C Disease (SC), sickle beta 0 thalassemia (ST0), sickle beta plus thalassemia (ST+), hemoglobin c disease (C). If a normal allele is present (A) in any of the genotypes, example “AS”, the person is a carrier. (Vedro, 2002).